Category: Research

Latest research or review of literature for oesophageal cancer or oeshophagectomy

German FLOT trial and a UK centre response

This citation is for the German FLOT4 trial which was instrumental in many centres changing from the former regimen of epirubicin, cisplatin, 5-FU (ECLF/ECX) to 5-FU, leucovorin, oxaliplatin and docetaxil/Taxotere (FLOT) due to the increased effectiveness and increased safety reported.

NB T1 tumours were excluded from the FLOT4 trial.

Although seemingly less harsh, FLOT is not a walk in the park and still has its fair share of side effects as shown by this poster from the Annals of Oncology written by the team from Christie in Manchester UK.

Needless to say, more and more centres seem to be using FLOT as the standard chemotherapy for oesophageal cancer.